Mal de Debarquement Syndrome (MDDS) is a condition characterized by a constant feeling of rocking/swaying. Usually, this comes on after a boat ride (hence the name). It can also occur after a plane, train, or car ride or even spontaneously. Often patients feel better if they are back in a car, boat, plane or train. There may be overlap with chronic subjective dizziness. Some patients have other symptoms of sensory sensitization.

The cause and best treatment for MDDS are not clear. Some patients improve spontaneously. For others, the problems persist. Some benefit from the drug Clonazepam (or Diazepam). This is however potentially addictive medication. I have successfully treated some patients with Venlafaxine (an antidepressant class drug). The medication has to be started at the lowest dose (or even half of the lowest strength tablet) and very gradually increased. Other treatments tried include magnetic stimulation (see here).

In order to prevent exacerbation of MDDS with travel on planes/boat/train etc patients can opt to take Diazepam or Clonazepam. Obviously, they can drive and will be somewhat sedated with these medications.

Optokinetic Treatment

Recent research by Dr Dai et al in 2014 (see here) has suggested that optokinetic visual stimulation (optokinetic treatment) can help some patients. Patients with MDDS were placed in a room with a screen with a moving black/white stripe pattern (it is important that the whole visual field is covered) while their heads were tilted/rolled (see video below) 20 degrees from side to side (ear to shoulder alternatively) by an assistant for 3 to 5 minutes, 1 to 8 times a day for 1 week. The pattern either moves from left to right or vice versa. The direction of movement of the visual field (to left or to right) was determined by some balance tests. The sway frequency of the side to side tilt was determined by the patient’s own rocking/sway frequency.

This treatment has been replicated with some success at other centers. In the UK as of Jan 2021, I am not aware of this treatment is available in the NHS.  The success is somewhere between 50 to 70%.

I recognize many patients with MDDS suffer greatly from this condition. I have therefore modified the treatment as proposed by Dr Dai to allow it be delivered at home. I have had limited success in some patients but not enough to state the treatment proposed below is successful.

YouTube recently introduced 360-degree videos. This, therefore, allows optokinetic type treatment at home. Some equipment including (at present) a high-end Android smartphone (a phone model with a built-in gyroscope/accelerometer is required) or iPhone and Google Cardboard Type virtual reality (VR) goggles (see here) or equivalent will be required.  This or a similar headset may therefore be more suitable for patients with glasses. High-end phones such as iPhones and Samsung Galaxy Note and S model have the required built-in gyroscope/accelerometer. If you are planning on purchasing an Android phone for this purpose you will need to check with the retailer if it has this ability. It may be possible to try a phone in the shop one a 360 YouTube video to see if it works as required.

You will also require an internet connection usually via WiFi.

There is no guarantee that this treatment will be successful.

I have created a 360-degree optokinetic video. To obtain the optokinetic effect these will have to be viewed with VR Goggles. Looking at a computer screen is unlikely be effective. The whole visual field will need to view the optokinetic video.

I have loaded these videos on to youtube:

Optokinetic pattern with movement to right

Optokinetic pattern with movement to the left

360 degrees video is a new format of video which allows the viewer to see all around via VR goggles. Google (who own YouTube) has created a standard for a type of budget Goggles that can be replicated and reproduced cheaply (Google Cardboard). These types of Goggles can be purchased from various makers (including Amazon or eBay) for as little as £20. Trying searching “Google VR” on Amazon. Make sure the Goggles suit your type of phone. Some will be more customizable and allow for example adjustment for focus and inter-pupillary distance. They are designed to work with a relatively high-end smart mobile phone. The key feature allowing a true virtual experience is the ability for the smartphone’s inbuilt detectors to keep the visual field level while the viewer moves his/her head. Watching a normal video through the Goggles with a smartphone does not replicate this.

The viewing angle with these goggles is somewhat limited. It may be possible to replicate the optokinetic treatment using the virtual reality Goggles playing the optokinetic video as carried out by Dr. Dai et al.

Prior to carrying out the treatment, Dr. Dai et al determined 2 pieces of information to guide the treatment: Rotation and Sway frequency.

1. Rotation

In some patients, it is possible to determine whether the video rotation to the left or right will be beneficial. This can be potentially determined by a patient walking on the spot with eyes closed for 1 minute. This should be repeated twice. If the patient turns to the left then the video to the right can be used for therapy and vice versa. In Dr. Dai et al research video-nystagmography was also used to determine which video to use but it will not be possible to do this at home without specialist equipment. In some patients, it was not possible to determine which rotation to use. In these cases, the patient was tried with one and then the other to see which provided benefit.

2. Sway Frequency

The researchers used a balance platform and a wrist accelerometer to determine the sway frequency. Again I suspect it may be possible for an independent viewer to look at a patient trying to stand still with eyes close to get an idea of the sway frequency. The patient themselves could also count out the number of sways (while eyes closed) in a minute. This figure can be divided by 60 to determine the frequency. In Dr. Dai et al paper this averaged at 0.2 Hz. i.e. the patient was swaying at a rate once every 5 seconds. If the sway frequency can be determined or estimated then this can be used to determine the frequency of rolling/tilting of the head during the treatment session. An assistant can then tilt the head from side to side (bringing the ear close to the shoulder) at this frequency during the treatment session. Assume we have a case with a frequency of 0.2 Hz. Starting with the head in neutral position followed by tilt to left then to right and then straight should take 5 seconds.

Setting up android phone for viewing 360 videos

Head Rolling/Tilting approximately 20 degrees / 0.2 Hz., while wearing a Google Cardboard VR Goggles.

Treatment

Dr Dai et al treatment consisted of viewing the optokinetic video stimulation (either to the left or right) while the head was tilted (rolled) 20 degrees side to side by an assistant at the sway frequency (see 2. above) for between 3 to 5 minutes. This was repeated 1 to 8 times a day for 1 week.

Once the VR Googles have been obtained they are assembled as per manufactures instructions. The relevant You Tube video is started on the smart phone (using the You Tube app). If the video is paused or the screen taped a menu appears on the screen. On the right upper part of the video are 3 dots in a vertical row (setting menu). This is pressed and another menu appears. Press the Cardboard icon. The video now splits in to 2. The video will also restart. The smart phone can now be inserted in to the Goggles. Looking straight ahead will give the optokinetic stimulus. Looking down or up reveal that impression you are in a tube. The head can now be tilted 20 degrees side to side at the sway frequency for the desired amount of time. Some patient may not be able to tolerate this very well and may feel nauseous.

There is also the theoretical potential for some patient to feel increased dizziness.

In the treatment by Dr Dai et al the patients scored their problem between 0 (no rocking) to 10 (most severe) before and after the treatment. The patient average score improved from 6.8 to 0.7. The patient rocking was also assessed with a balance platform. The results that Dr Dai et al have obtained seem impressive. From the 24 patient treated 70% improved and none deteriorated.

I would not recommend this treatment for patients who have photosensitive epilepsy.

 

Results

In a one-word mixed. Some patients have benefited while others have not.

A success story:

Please can you inform Dr Rejali that my VR goggles have improved my feeling of staggering connected to my MdDB so very pleased. I still have the blocked left ear and a bit tired but much better.

News

14/06/2020

A message from Polly Moyer tireless campaigner for MDdS:

Darius,
Today the lovely people at crowd science (who are hosting the MdDS research crowdfunding campaign) updated their information and it’s exciting to see new researchers in the consortium.  I’d be very grateful if you can circulate this information amongst your professional network.
All best wishes,
Polly

Polly Moyer MA

 

20/10/2019

A new survey on MDDS: https://mdds2019.questionpro.com/

 

8/2/19

Darius,
I hope this finds you well.  As part of her prize from Future Science, Vivi is giving a webinar on MdDS on Feb 28th (Rare Diseases Day – although that might be a co-incidence).  I’d be grateful if you could let your colleagues know about this and if you can promote it via your MdDS pages, that would be grand.
#MdDSresearch
All best wishes,
Polly

 

13/09/18

Darius,
Some exciting news in the run up to Balance Awareness Week.  My friend Vivi, who has been researching MdDS, has reached the final of an Early Career Award.  The winner will be decided by popular vote, which never favours ‘rare’ researchers, so I am campaigning on her behalf and asking people to consider voting for her.  It’s very quick and easy to do – here’s the link:
Please also consider sharing this with your personal/professional network – a vote for Vivi is a vote for vestibular research 🙂
Regarding work adjustments, below is a list of the issues that get mentioned most frequently.  There are others but these are a good place to start so I hope you can put them on your MdDS page.
Many thanks and all best wishes,
Polly

Recommended workplace adjustments and hacks for people with Mal de Debarquement Syndrome (MdDS) to maintain/improve productivity.

Work in natural lighting whenever possible

Rehydrate – little and often

Try to avoid working in visually ‘busy’ environments

Reduce glare and blue light from computer screens

Take regular breaks from screen use and go outside if you can

Avoid working in spaces where there are strong smells, including after-shave and scent

If you use the telephone a lot, consider using a head-set so you have even audio input

Avoid using shuttle buses

Service (enclosed) elevators may be preferable to glass ones.  [Worth noting that MdDS is a spectrum condition and some people with this condition may not do well in enclosed spaces and/or that this may change, over time]

If your job involves walking and/or standing in line (eg in a canteen), consider using a walking cane for added proprioceptive input and extra stability